Ozempic and Wegovy seem to have been everywhere for the past few years, and these drugs may have changed the way we approach weight loss. Could losing weight be this simple? Seeing celebs like Oprah flaunt their new slim bodies and admitting to relying on the new generation of weight loss drugs, no wonder that more and more people are trying it too. But there are some things you should know before you start those weekly injections.
Ozempic, initially designed as a treatment for Type 2 diabetes, has found itself in the spotlight for its potential as a weight loss aid. However, amidst the buzz, it’s crucial to understand the facts behind the headlines and discern the reality of Ozempic’s role in weight management.
Understanding Ozempic and Its Mechanism
Ozempic, containing the active ingredient semaglutide, was first approved by the FDA in 2017 for managing diabetes. Semaglutide works by regulating insulin and mimicking a hormone called glucagon-like peptide-1 (GLP-1), which helps control blood sugar levels and suppresses appetite. This dual action not only aids in managing diabetes but also shows promise in promoting weight loss. Basically, people on Ozempic are not as interested in food and don’t have cravings.
The Rise of Off-Label Use
While initially intended for diabetes management, Ozempic’s weight loss potential has sparked interest beyond its original purpose. The FDA’s approval of a higher-dose version of semaglutide, known as Wegovy, specifically for weight loss, further fueled this interest. Off-label use of Ozempic for weight loss has become increasingly common, driven by testimonials on social media and celebrity endorsements. Oprah, for example, has been very vocal about her positive experience with Ozempic and how it changed her life.
However, it’s essential to recognize that using medications off-label comes with risks and uncertainties. Fitness celebs and trainers like Jillian Michaels are strongly against these medications. Michaels consistently emphasizes the lack of long-term research and serious side effects that already manifest in individuals taking these drugs. “With anything medical, whether we’re talking about a vaccine or antibiotics, there’s always side effects,” she explained to the outlet, listing the potential downsides. “So let’s start out with the side effects that are on the f***ing website: We’ve got thyroid tumours, gallbladder problems, pancreatitis, kidney issues, vision loss, stomach problems now including stomach paralysis. There’s a class action lawsuit for stomach paralysis,” says Michaels.
Evaluating Effectiveness and Safety
Studies sponsored by Novo Nordisk, the manufacturer of Ozempic, suggest that individuals using semaglutide may experience weight loss. Clinical trials have demonstrated significant weight loss among participants with obesity or excess weight. However, it’s crucial to note that the dose used in these trials exceeds that typically prescribed for diabetes management. Additionally, while Ozempic is generally safe when used as directed, it may cause gastrointestinal side effects such as nausea and diarrhoea.
In its recent piece, The New York Times interviewed Dr. Janice Jin Hwang, chief of the division of endocrinology and metabolism at the University of North Carolina School of Medicine. For patients taking the medication, “foods that used to be really exciting to them are no longer exciting,” she said. Some people report that their “food noise,” or ruminations about food, disappear after taking drugs like Ozempic. The medication has not been significantly studied in people without diabetes or excess weight.
The medication can also reduce the risk of cardiovascular disease for people with diabetes, said Dr. Robert Gabbay, chief scientific and medical officer of the American Diabetes Association.
The FDA has not approved Ozempic for weight loss, noted Dr. Andrew Kraftson, a clinical associate professor in the division of metabolism, endocrinology and diabetes at Michigan Medicine. But after the FDA authorized Wegovy for weight loss, there was such demand for the drug that some providers turned to Ozempic when they couldn’t get Wegovy, he explained.
“These drugs were not designed for normal-weight people who want to get down to be super thin,” Dr. Hwang said.
Navigating Prescription and Coverage
Accessing Ozempic for weight loss purposes can present challenges, particularly regarding prescription and insurance coverage. While some healthcare providers may prescribe it off-label for weight management, insurance coverage for this indication is limited. Furthermore, the high cost of Ozempic may pose a barrier to those without adequate insurance coverage. For instance, a 0.25 or 0.5 milligram dose of Ozempic currently retails on the Novo Nordisk website for $935.77 without insurance. However, those with private or commercial insurance who are eligible for prescription may pay as little as $25 for a one-, two- or three-month supply, according to the company.
Consulting with Healthcare Professionals
Before considering Ozempic for weight loss, one should consult with their healthcare provider. Healthcare professionals can assess the appropriateness of Ozempic based on your unique health status, considering factors such as diabetes management, weight-related conditions, potential thyroid problems, and potential risks. Additionally, they can provide guidance on dosage, monitoring, and long-term management.
However, according to the in-depth article done by Forbes, using Ozempic for short-term, cosmetic weight loss is not something doctors recommend. “While this has received significant attention in the media, Ozempic and related GLP-1 medications are not designed to be used in this way, can lead to potential adverse events and ultimately the weight that is lost will be regained. Further, this off-label use of Ozempic is greatly impacting availability of the medication for those who need it most—individuals with type 2 diabetes (or in the case of Wegovy, individuals with obesity).
Final Thoughts
While Ozempic holds promise as a weight loss aid, it’s essential to approach its use with caution and make informed decisions. Understanding its mechanism, effectiveness, and safety profile is crucial for individuals considering it for weight management. Ultimately, while Ozempic may offer benefits for some individuals, it’s not a one-size-fits-all solution – in fact, neither of weight management solutions are. Please do your own research and consult experts before going on any medication, not just Ozempic/Wegovy.
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